After an acting career spanning some sixty five years, Tandy found latter-day movie stardom in major-studio releases and intimate dramas alike. From a young age she was determined to be an actress, and first appeared on the London stage in 1926, playing, among others, Katherine opposite Laurence Olivier's Henry V, and Cordelia opposite John Gielgud's "King Lear". She also worked in British films. Following the end of her first marriage, she moved to New York and met Canadian actor Hume Cronyn, who became her second husband and frequent partner on stage and screen. She made her American film debut in The Seventh Cross (1944). She also appeared in The Valley of Decision (1945), The Green Years (1946, ironically enough as Cronyn's daughter!), Dragonwyck (1946) starring Gene Tierney and Forever Amber (1947). After her Tony-winning performance as Blanche DuBois in the original Broadway production of Tennessee Williams' A Streetcar Named Desire, she concentrated on the stage and only appeared sporadically in films such as The Light in the Forest (1957) and The Birds (1963).
The beginning of the 1980s saw a resurgence in her film career, with character roles in The World According to Garp, Best Friends, Still of the Night (all 1982) and The Bostonians (1984), and the hit film Cocoon (1985), opposite Cronyn, with whom she reteamed for *Batteries not included (1987) and Cocoon: The Return (1988). She and Cronyn had been working together more and more, on stage and television, to continued acclaim, notably in 1987's Foxfire which won her an Emmy Award (recreating her Tony-winning Broadway role). However, it was her colorful performance in Driving Miss Daisy (1989), as an aging, stubborn Southern-Jewish matron, that made her a bonafide Hollywood star and earned her an Oscar. She was the oldest actor to ever win an Academy Award, beating out George Burns by less than a year.
She was chosen by People magazine as one of the fifty Most Beautiful People in the world in 1990.
She subsequently earned a Best Supporting Actress nomination for her work in the grass-roots hit Fried Green Tomatoes (1992), and co-starred in The Story Lady (1991 telefilm, with daughter Tandy Cronyn), Used People (1992, as Shirley MacLaine's mother), To Dance with the White Dog (1993 telefilm, with husband Hume Cronyn), Nobody's Fool (1994), and Camilla (also 1994, with Cronyn). Camilla was to be her last performance, and it was bold in one way that she, at the age of about eighty four and knowing that she was dying, had a brief nude scene, which could also be called "cheeky".
She died at home on September 11, 1994, in Easton, Connecticut, of ovarian cancer at the age of eighty five. Prior to moving to Connecticut, she lived with Cronyn for many years in nearby Pound Ridge, NY on land adjacent to their dear friends (and Cronyn's cousin), the producer Robert Whitehead and actress Zoe Caldwell